2016 Fiscal Year Final Research Report
Identification of novel cancer antigens for oral squamous cell carcinoma and research towards clinical application
Project/Area Number |
26463051
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
|
Research Institution | Sapporo Medical University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 口腔癌 / 腫瘍免疫 |
Outline of Final Research Achievements |
Aiming at establishing a pair of autologous cancer cell line and its CTL for the identification of novel cancer antigen, Sapporo Medical University Hospital Dental Department of Oral Surgery than the biopsy tissue of cheek oral squamous cell carcinoma patient treated In the establishment of a cell line successfully, PBL or TIL of a patient with established cancer cell line was isolated, cultured in AIM-VRMedium supplemented with rI l -2 (50 IU / ml), and irradiated with X rays Mixed culture of autologous cancer cell line and PBL or TIL was repeated, induction of CTL succeeded in establishing pair of autologous cancer cell line and its CTL. Analysis of autologous cancer-specific cytotoxicity mechanism was carried out.
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Free Research Field |
口腔外科
|