2016 Fiscal Year Final Research Report
Molecular pathology of phenotypic chenges in lesions of jow bones
| Project/Area Number |
26463054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TSUJIGIWA Hidetsugu 岡山理科大学, 理学部, 教授 (70335628)
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| Research Collaborator |
SHIMADA Katsumitsu
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 分子病理学 / 臨床腫瘍学 / 形質発現 |
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| Outline of Final Research Achievements |
Odontogenic lesions sometimes appear many kinds of abnormal morphologic chenges. Therefore, we examine the localization of neuroendocrine cell markers and cornified cell envelop (CE) related proteins in odontogenic lesions. CD56 and synaptophysin co-expressed in some parts of columnar cells in ameloblastomas. Furthermore, the mRNA expressed both CD56 and synaptophysin. CE related proteins showed various expression depending on the lesions. Our result suggest that CD56-positive cells partially differentiated into synaptophysin-positive cells in ameloblastomas. CE related proteins play important roles in odontogenic lesions. The examination of neuroendocrine cell markers and CE related protein expression could clarify the differentiation of some odontogenic lesions.
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| Free Research Field |
口腔病理学
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