2016 Fiscal Year Final Research Report
Central nervous regeneration by transplantation of dedifferentiated fat cell in mouse brain infarction model
| Project/Area Number |
26463082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUYAMA Tomohiro 兵庫医科大学, 医学部, 教授 (10219529)
MAEDA Mitsuyo 公益財団法人先端医療振興財団, 再生医科学研究所, 研究員 (40122080)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 脱分化脂肪細胞 / 脳梗塞 / 中枢神経 / 細胞移植 / 再生 |
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| Outline of Final Research Achievements |
We isolated the dedifferentiated fat (DFAT) by ceiling culture of mature adipocytes obtained from human buccal fat pads.DFAT expressed neuronal markers nestin, sox2. Moreover, it had properties similar to those of mesenchymal stem cells from Flow cytometric analysis. Although there was no difference in the infarct side surface area by xenografting these cells to a cerebral infarction disease model mouse, functional recovery was observed in the behavioral test. In addition, DFAT transplanted into mice was detected in cerebral infarct lesion. Therefore, the possibility that transplanted DFAT influences brain after infarction and contributes to promotion of functional recovery was considered.
This finding suggested the possibility of a new source of cell replacement therapy for the treatment of central nervous disorders.
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| Free Research Field |
歯科麻酔学
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