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2016 Fiscal Year Final Research Report

Moleculr mechanism of CTGF and Odz3 in biological response of sutures to tensile force

Research Project

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Project/Area Number 26463084
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

Takeshita Nobuo  東北大学, 歯学研究科, 助教 (50431515)

Co-Investigator(Renkei-kenkyūsha) RYUSHI KATO  東北大学, 大学院歯学研究科, 大学院非常勤講師 (90706699)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords縫合 / CTGF / 牽引力
Outline of Final Research Achievements

We have analyzed the function of CTGF during biological response of cranial sutures to tensile force. Tensile force induced the expression of Ctgf and Vegf in sutures 3 hours after loading. The tensile force-induced Vegf expression in sutures was inhibited by the administration of CTGF-neutralizing antibody. The administration of CTGF-neutralizing antibody also inhibited sutural bone formation induced by tensile force. Moreover, we have cultured primary suture-derived cells to analyze CTGF function in vitro. Our findings indicate that CTGF is an essential factor to regulate biological response of sutures to tensile force.

Free Research Field

歯科矯正学

URL: 

Published: 2018-03-22  

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