Biological responses due to bacteremia following scaling and application effects of optical energy

2017 Fiscal Year Final Research Report

• Project/Area Number: 26463132
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Niigata University
• Principal Investigator: MOROZUMI TOSHIYA 新潟大学, 医歯学総合病院, 助教 (20444151)
• Co-Investigator(Kenkyū-buntansha): 小松 康高 新潟大学, 医歯学総合病院, 助教 (40422597) ; 清水 太郎 新潟大学, 医歯学総合病院, 医員 (60609121) ; 久保田 健彦 新潟大学, 医歯学総合病院, 講師 (50303136)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 生体応答 / 炎症性サイトカイン / スケーリング / ミノサイクリン / 抗菌的光線力学療法

Outline of Final Research Achievements

Intense non-surgical periodontal therapy including scaling and root planing (SRP) acts as a potent inflammatory stimulus immediately after treatment, and induces an acute inflammatory response. In the study, we demonstrated that full-mouth SRP produced a moderate systemic acute-phase response 1 day post-treatment, while pre-treatment of azithromycin could inhibit the those response. In addition, we found that local administration of minocycline ointment may slightly help to improve clinical, microbiological, and crevicular cytokine levels in periodontal pockets not yet treated with subgingival scaling.

Free Research Field

歯周病学, 歯周治療学