2016 Fiscal Year Final Research Report
The effect of cell-derived microparticles on the homeostasis of periodontal tissue
| Project/Area Number |
26463133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | マイクロパーティクル |
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| Outline of Final Research Achievements |
We have examined the effect of cell-derived microparticles (MP) on homeostasis of gingival cells. Endothelial cell-derived microparticles (EMP) released from the cells with LPS or inflammatory cytokine expressed annexin, ICAM-1 and HLA-DR higher than EMP from the non-stimulated cells. IL-8 expression in human gingival fibroblasts in the presence of EMP released from the cells with LPS or inflammatory cytokine was significantly elevated compared with EMP from non-stimulated cells. These results suggested that MP released from cells stimulated with inflammatory stimulation could be inflammatory factor.
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| Free Research Field |
歯周病学
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