Potential role of IL-1 family cytokines in periodontal diseases

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463150
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Osaka Medical College (2016); Hyogo Medical University (2014-2015)
• Principal Investigator: Ohyama Hideki 大阪医科大学, 医学部, 非常勤講師 (90280685)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: IL-36 / 歯肉上皮細胞 / 歯周病

Outline of Final Research Achievements

We evaluated the expression of IL-1 family cytokines in the periodontal tissue of periodontitis patients. We focused on the expression of IL-36γ as it was found to be highly expressed in the gingival epithelium. We found that the expression of IL-36γ in gingival epithelial cells was significantly induced by IL-1β, TNF-α, IL-17, and Porphyromonas gingivalis. In addition, the IL-36γ expression level increased with differentiation of gingival epithelial cells. These results suggest the potential role of IL36γ in periodontal diseases.

Free Research Field

歯周病態学