2016 Fiscal Year Final Research Report
Sphingomyelin regulates blood glucose levels by bone tissue
| Project/Area Number |
26463202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 骨代謝 |
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| Outline of Final Research Achievements |
The skeleton has been shown recently to regulate glucose metabolism through an osteoblast-specific hormone. Here, we investigated the role of sphingomyelin in osteoblasts. Knockdown of sphingomyelin synthase 1 or 2 resulted in inhibited osteoblast differentiation and reduced osteoclast formation. We found that sphingomyelin synthase affected osteoblast function, and we suggested sphingomyelin synthase effects to regulate glucose metabolism by osteoblast.
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| Free Research Field |
生化学
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