2016 Fiscal Year Final Research Report
Morphological study of angiogenesis and type III collagen synthesis in diabetic wound healing
| Project/Area Number |
26463213
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fundamental nursing
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| Research Institution | Saitama Prefectural University |
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Principal Investigator |
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| Research Collaborator |
GOMI Toshiaki
KIMURA Akihiko
TERAJIMA Miho
ITOH Sayami
IWATA Kayako
KONG Lingshuai
UTHIKURA Chie
OOTAKE Emi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 創傷治癒 / 糖尿病 / 血管新生 / VEGF / 免疫組織化学 |
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| Outline of Final Research Achievements |
The wound healing in diabetes was taken for morphological analyses. For the experiments, diabetic male mice were used and immunohistological analysis for angiogenesis, blood flow and formation of type III collagen.
As a result, a delay of 2 to 3 days was observed in angiogenesis in wound healing process in diabetes than in normal cases. Blood flow was observed in new blood vessels after 1 or 2 days. Formation of type III collagen was observed consistent with the onset of blood flow. These results may suggest that the cause of delay in wound healing in diabetic mice is one of the causes of the delay in angiogenesis and the delay in starting blood flow, which makes it impossible to supply the wound with the nutrition
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| Free Research Field |
組織学
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