Novel mechanisms for unabosorbable food factors with anti-life style-related deseases activities

2016 Fiscal Year Final Research Report

• Project/Area Number: 26500003
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: MIURA Yutaka 東京農工大学, (連合)農学研究科(研究院), 教授 (10219595)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: スフィンゴミエリン / 生活習慣病 / 腸管透過性 / エキソソーム

Outline of Final Research Achievements

Some food factors are difficult to be absorbed from an intestinal tract, although they showed clear physiological functions. To elucidate the mode of actions of such unabsorbable food factors, the effect of sphingomyelin (SPM) on the intestinal permeability and serum exosomes was investigated. SPM is shown to increase the intercellular permeability of the intestinal epithelial cells, which may be one of the mechanisms of sphingomyelin functions. Serum exosomes could increase glucose uptake by L6 myotubes and dietary SPM augmented the serum exosome functions. These results suggest novel mode of actions of SPM via intestinal tracts and serum exosomes.

Free Research Field

栄養化学