2016 Fiscal Year Final Research Report
Analysis of prevention of Alzheimer's disease based on underlying pathology
| Project/Area Number |
26500006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 小胞体ストレス / フラボノイド / 認知症 / 記憶 / 想起 |
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| Outline of Final Research Achievements |
Purpose of this study is to explore the action of quercetin and its target gene GADD34 for amyloid-beta production and impairment of learning and memory in Alzheimer’s disease (AD) model mice APP23. In addition, pilot study of intervention trial of quercetin high content onion to early stage AD patients was carried out. In this study, deterioration of memory impairment was delayed in AD mice feeding quercetin-containing food compared with AD mice feeding control food. The levels of GADD34 in the brains of AD mice feeding quercetin-containing food were higher than those of AD mice feeding control food. In addition, score of recall using HDS-R in early stage AD patients was significantly improved. These results suggest that quercetin may be promising functional food molecule to prevent memory impairment.
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| Free Research Field |
神経内科
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