Onset mechanisms of atopic dermatitis induced by saturate fatty acid of breast milk

2016 Fiscal Year Final Research Report

• Project/Area Number: 26500010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Hiroshima University
• Principal Investigator: Kanno Masamoto 広島大学, 医歯薬保健学研究院(医), 教授 (40161393)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アレルギー疾患 / アトピー性皮膚炎 / 母乳 / 自然免疫系 / 自然リンパ球 / メタボローム解析 / マウス発症モデル

Outline of Final Research Achievements

Breastfeeding is believed to influence the infants’ immune system development and may even affect various immunological responses later in life. A cohort study was carried out to monitor atopic dermatitis(AD) development in breast-fed children. About 10% of the AD+ mothers milk was positive (DAMPs+) when introduced to human cells in vitro. To identify the DAMP molecules, targeted metabolomics analysis was performed. This indicated presence of higher amount of several saturated fatty acids (SFA). In vivo study of HR-1 hairless mice breast-fed on lactating period with high SFA diet showed a higher incidence of skin eczema and AD-like skin symptoms. We are focusing on innate immunity and how SFA promote skin eczema and IgE increase. Among the changes observed in high SFA-milk diet mice include alterations in the intestinal and skin lymphocytes development. We concluded immunological mechanisms and aspect of nutrition based development mechanisms of atopic dermatitis.

Free Research Field

免疫学