Elucidation of relationships between sleep apnea and fluid shift in heart failure

2016 Fiscal Year Final Research Report

• Project/Area Number: 26507010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 睡眠科学
• Research Institution: Juntendo University
• Principal Investigator: Kasai Takatoshi 順天堂大学, 医学(系)研究科(研究院), 准教授 (60465036)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 睡眠医学 / 心不全 / 睡眠呼吸障害

Outline of Final Research Achievements

Coexistence of sleep apnea (SA), a treatable comorbidity, leads poor prognostic in patients with heart failure (HF). Reportedly, fluid redistribution from the legs to the upper body during sleep can contribute to the pathogenesis of SA in HF patients. We conducted investigations to further elucidate relationships between SA and fluid shift in HF. We found and reported that in patients with acute HF, volume of fluid shift correlated with severity of SA, and that following standard treatment of acute HF, SA was alleviated in association with reductions of fluid shift volume. In addition, we found and reported that in patients with mitral regurgitation, volume of fluid shift correlated with severity of SA, and that following surgery for mitral regurgitation, SA severity changed in association with changes in fluid shift volume. Further investigation whether cardiac rehabilitation can alleviate SA in association with reductions in fluid shift volume is on ongoing.

Free Research Field

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