Identification of diet contents regulating RNA methylation and those effects on fetal growth

2016 Fiscal Year Final Research Report

• Project/Area Number: 26560076
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: National Center for Child Health and Development
• Principal Investigator: Kawai Tomoko 国立研究開発法人国立成育医療研究センター, 周産期病態研究部, 室長 (40423404)
• Research Collaborator: Taniguchi Kosuke
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胎児発育 / 胎盤 / RNAメチル化

Outline of Final Research Achievements

Adenine methyl modification of mRNA is known to regulate mRNA fates and alter the mRNA function. The reports elucidating mRNA methylation roles in the specified cells are increasing in an exponential manner. On the other hands, the studies exploring the mRNA methylation status at transcriptome-wide manner in vivo are limited. We investigated human placental transcriptome-wide methylation status and revealed that placental post-transcriptional gene expression regulation mechanism through mRNA methylation might be associated with fetal growth.

Free Research Field

栄養学　分子生物学