Improvement of the fiber orientation of stem cell-based self-assembled tissues cultured in a magnetic field via a Hallbach array

2016 Fiscal Year Final Research Report

• Project/Area Number: 26560218
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: FUJIE HIROMICHI 首都大学東京, システムデザイン学部, 教授 (20199300)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 間葉系幹細胞 / 静磁場 / ハルバッハ配列磁界 / 細胞接着

Outline of Final Research Achievements

It is necessary to promote the generation of extracellular matrix of mesenchymal stem cell (MSC)-based self-assembled tissue (scSAT) for a better application of the scSAT to tissue repair. In this study, MSC was cultured in static magnetic field of 0.674 T via Halbach cylinder-like array. As a result, the cell adhesion area was significantly increased at 18 days while the cell occupation ratio significantly decrease at 25 days in magnetically stimulated cells. However, no obvious differences were observed in cell number, aspect ratio, and orientation angle. It is suggested that the MSCs are affected by static magnetic field of 0.674 T.

Free Research Field

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