Persistent luminescence nanoparticles applicable for in vivo imaging of cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560220
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Nara Medical University
• Principal Investigator: Nishi Mayumi 奈良県立医科大学, 医学部, 教授 (40295639)
• Co-Investigator(Kenkyū-buntansha): HORII Noriko 奈良県立医科大学, 医学部, 助教 (80433332)
• Co-Investigator(Renkei-kenkyūsha): TAKI Masayasu 名古屋大学, 理学部, 特任准教授 (70378850)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 長残光蛍光ナノ粒子 / in vivo イメージング / 担癌マウス / 無侵襲 / 低毒性

Outline of Final Research Achievements

For developing the innovative probe of persistent luminescence nanoparticles applicable to medicine, we aimed at bioimaging without irradiation to visualize tumor cells in living animals. After transplanting human osteosarcoma (HOS) into subcutaneous of SCID mouse, antibody agaisnt HOS labeled with photactivated persistent luminescence nanoparticles was intravenously injected to this SCID mouse. We successfully peformed in vivo imaging of HOS by using photocouting system, IVIS Imaging System.

Free Research Field

神経解剖学