An application of integrated microcapsule technology for preparation of cell-specific scaffold

2016 Fiscal Year Final Research Report

• Project/Area Number: 26560236
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Gunma University
• Principal Investigator: DOBASHI TOSHIAKI 群馬大学, 大学院理工学府, 教授 (30155626)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 足場 / 細胞接着 / 細胞増殖 / ゲル / 紫外線

Outline of Final Research Achievements

Human fibroblast cells WI-38 can be cultured on a UV-irradiated gelatin microcapsule scaffold, whereas cancered cells WI-38-VA-13 can not be grown on the microcapsules. In this study we tried to determine the preparation condition of such cell-specific scaffolds and develop a new technology using the scaffold for medical applications. We found that (1) the cell-specific property is controlled by dose of UV irradiation, (2) the cell-specificity depends on the differentiation degree of stomach cancer cells, and the cell adhesion and proliferation can be modified by the combination of scaffold and anti-cancer agent.

Free Research Field

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