Quantitative imaging of the target fluorescent substance by fluorescence multispectral endoscope

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560267
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: National Defense Medical College
• Principal Investigator: Morimoto Yuji 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 准教授 (10449069)
• Co-Investigator(Kenkyū-buntansha): IWAYA Keiichi 公益財団法人佐々木研究所, その他の部局等, 研究員 (50312012)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 画像診断システム / 内視鏡 / 蛍光

Outline of Final Research Achievements

To achieve a quantitative imaging of labeled fluorescent substances, a novel endoscopic system equipped with a fluorescence multispectral imaging system coupled to the spectral unmixing function was established. This system can visualize a fluorescence spectral unmixing image with a rate of 1 f/s. We verified the detectability of the newly developed endoscopic system for pathological lesions. Using a mouse atherosclerosis model or a rat esophageal tumor model, we succeeded to clearly visualize an atherosclerotic plaques or esophageal tumors in real time.

Free Research Field

光医学、生理学、イメージング