Structural changes of the central nervous system by BTX-A injection with exercise therapies

2017 Fiscal Year Final Research Report

• Project/Area Number: 26560291
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Osaka Medical College
• Principal Investigator: Ryuichi Saura 大阪医科大学, 医学部, 教授 (10252769)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ボツリヌス毒素療法 / リハビリテーション治療 / 痙縮 / 脳血管障害 / 脊髄損傷

Outline of Final Research Achievements

Change of the central nervous systems were examined using MRI imaging and clinical indicators such as modified Ashworth scale (MAS) and functional independent measure (FIM). Also, amount of the Quality of life was measured and degree of the depression and self-efficacy were evaluated after the Botulinum Toxin Type A injection with or without rehabilitation exercises. Significant improvement of the upper and lower extremities functions was observed by the BTX-A injection with rehabilitation exercises in compared with the BTX-A injection alone. However, no findings were observed in terms of the MRI imaging evaluation on Neuro-network reconstruction of the central nervous systems. It is, therefore, suggested rehabilitation exercises with decreased spasticity by BTX-A injection were very useful for the patients with spastic motor dysfunction in spite of the unknown conditions of MRI imaging.

Free Research Field

リハビリテーション医学