2015 Fiscal Year Final Research Report
Amino acid nutrition for promoting the efficacy of exercise training
| Project/Area Number |
26560366
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Sports science
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KITAURA Yasuyuki 名古屋大学, 大学院生命農学研究科, 助教 (90442954)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 分岐鎖アミノ酸 / 分岐鎖α-ケト酸脱水素酵素キナーゼ / 運動トレーニング / 持久力 / マウス / コンディショナルノックアウト / 筋肉 |
|---|
| Outline of Final Research Achievements |
We produced muscle-specific branched-chain α-ketoacid dehydrogenase kinase (BDK)-deficient mice, in which the catabolism of branched-chain amino acids (BCAAs) were promoted in a muscle-specific manner. The mice showed decreased adaptability to exercise training compared to control mice. It was suggested that decreased muscle glycogen content, low activities of mitochondrial enzymes, derivatization of BCAA catabolites, and suppression of glycolysis were involved in the mechanisms.
|
| Free Research Field |
複合領域
|
