Creation of molecular delivery system using stimuli-responsive DNA nanostructures

2015 Fiscal Year Final Research Report

• Project/Area Number: 26620133
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bio-related chemistry
• Research Institution: Kyoto University
• Principal Investigator: Endo Masayuki 京都大学, 物質―細胞統合システム拠点, 准教授 (70335389)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: DNA / ナノ構造体 / DNAオリガミ / 光機能性 / 原子間力顕微鏡 / デリバリーシステム / 細胞機能制御

Outline of Final Research Achievements

For creating the basic technology to apply the functional DNA nano-sized structure to the cellular regulation, the novel DNA molecule system was developed and investigated. In this study, functional DNA nanostructures were created, and the opening and closing of the structure was performed by photoirradiation. Using these nanostructures, we have developed a new molecular system for controlling the inclusion and release of gold particles and enzyme activity. These photoresponsive DNA nanostructures created here can be used for delivery of the biomolecules into cells.

Free Research Field

生物有機化学