Does enzymatic activity involve in mitochondrial movement?

2015 Fiscal Year Final Research Report

• Project/Area Number: 26620135
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bio-related chemistry
• Research Institution: Kyushu University
• Principal Investigator: Koshiba Takumi 九州大学, 理学(系)研究科(研究院), 准教授 (70403970)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ミトコンドリア / 酵素活性 / GTPase

Outline of Final Research Achievements

Mitochondria are dynamic organelles that undergo continuous fusion and fission, and these processes are believe to be essential for physiologic function of organisms. Once their balances become to be disrupted, it has been revealed that much of unexpected influences accumulate on physiologic functions.
Our aims of the project is to elucidate their mystery of the mitochondrial shape, and try to understand the mechanism by a molecular level. In this study, we focused on the role of a mitochondrial GTPase, OPA1 and the regulatory molecule of metalloproteases. We identified that OPA1 processing by the proteases would be an essential process for the maintaining of mitochondrial morphology.

Free Research Field

タンパク質科学