2015 Fiscal Year Final Research Report
Long non-coding RNA associated with cancer stemness
| Project/Area Number |
26640073
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OHHATA Tatsuya 浜松医科大学, 医学部, 助教 (80616459)
KITAGAWA Kyoko 浜松医科大学, 医学部, 助教 (20299605)
NIIDA Hiroyuki 浜松医科大学, 医学部, 准教授 (20336671)
UCHIDA Chiharu 浜松医科大学, 光尖端医学教育研究センター, 准教授 (60223567)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | lncRNA / cancer |
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| Outline of Final Research Achievements |
In this project, we tried to identify long non-coding RNAs (lncRNA) associated with development of cancer cell and cancer stem cells. Moreover, we also investigated their function and regulation in molecular level. We found that expression of lnc RNA ANRIL, a lncRNA associated with cancerious self-growth, was suppressed by overexpression of activated Ras. In contrast, expression of lncRNA PANDA associated with apoptosis was upregulated. Moreover, we investigated a novel function of PANA in tumor suppression. We found that PANDA promoted stabilization of p53 protein. The result suggested that PANDA may be a tumor suppressor lncRNA.
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| Free Research Field |
分子生物学
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