Importance of Sytl/Slp family gene in leukemia

2015 Fiscal Year Final Research Report

• Project/Area Number: 26640085
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: Nakamura Takuro 公益財団法人がん研究会, その他部局等, その他 (00180373)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: がん細胞の特性 / Sytl1 / Meis1 / Hoxa9 / 骨髄ニッチ / CXCR4 / 白血病

Outline of Final Research Achievements

We identified Sytl1 as a direct transcriptional target for Meis1, and Sytl1 cooperates with Hoxa9. Sytl1 facilitates membrane trafficking of CXCR4, thus enhancing cell migration and engraftment. These results such as 1) Meis1 functions in leukemic cell homing and engraftment, 2) direct regulation of Sytl1 by Meis1, 3) SYTL1 expression in human AML, 4) Sytl1 function in migration and motility of leukemic cells and 5) membrane trafficking of CXCR4 by Sytl1 are quite novel and uncover the function of Meis1 in leukemia.

Free Research Field

腫瘍生物学