Synthesis of complex enzymes with rational spatial arrangement

2016 Fiscal Year Final Research Report

• Project/Area Number: 26640133
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: System genome science
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Watanabe Satoru 国立研究開発法人理化学研究所, 生命システム研究センター, 上級研究員 (80300945)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 酵素 / 人工代謝系 / 空間配置 / 遺伝子回路

Outline of Final Research Achievements

Owing to recent development of synthetic biology, a set of basic tools are now available by which you can design and prepare artificial genetic circuits. These circuits can synthesize desired compound but their efficiency is generally still low especially when they are composed of many enzymes and are complicated. In this research, I tried to control expression levels and spatial arrangement of these enzymes using artificial TAL effector.

Free Research Field

合成生物学