2015 Fiscal Year Final Research Report
Vesicular dynamics in parietal and muscle cells
| Project/Area Number |
26650034
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | MG53 / TRIM50 |
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| Outline of Final Research Achievements |
Mitsugumin 53 (MG53) is localized to repair vesicles underneath the cell membrane in muscle cells, and controls vesicular nucleation toward damaged sites during cell injury. TRIM50 is localized to tubulovesicles in in gastric parietal cells, and regulates vesicular dynamics during gastric acid secretion. MG53 and TRIM50 share a highly homologues structure, and we thus hypothesize that the repair vesicles and tubulovesicles may be regulated by similar molecular mechanisms. In this research project, we tried to identify structurally-similar components, for example, motor proteins and adaptor proteins to cytoskeleton, shared by muscular repair vesicles and parietal tubulovesicles.
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| Free Research Field |
生化学
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