2015 Fiscal Year Final Research Report
Elucidation of mechanisms that regulate neural generation spatio-temporally in the brain using living embryos
Project/Area Number |
26650077
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Developmental biology
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Research Institution | Kyoto University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SATO Fuminori 京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 (10588263)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Keywords | 発生・分化 / 組織・細胞 / 再生医学 / 生体分子 |
Outline of Final Research Achievements |
Post-mitotic neurons are generated from neural progenitor cells (NPCs) at the expense of their proliferation. Live imaging revealed how production of post-mitotic neurons from neural progenitor cells is regulated in the sub-ventricular zone (SVZ). This neurogenesis depends on Neuregulin 1 type II (NRG1-II)-ErbB signaling. Moreover, we developed a novel fluorescent probe, which enables us to monitor the activity of the NRG1 ecotodomain shedding. Expression of the probe in zebrafish embryos revealed involvement of the NRG1 ecotodmain shedding in the spatio-temporal regulations of its signaling,.
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Free Research Field |
発生生物学・細胞生物学
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