Development of Drosophila cell culture system to analyze cell chirality

2015 Fiscal Year Final Research Report

• Project/Area Number: 26650081
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Developmental biology
• Research Institution: Osaka University
• Principal Investigator: Matsuno Kenji 大阪大学, 理学(系)研究科(研究院), 教授 (60318227)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 細胞キラリティ / 細胞極性 / 左右非対称性 / 中心体 / ヘモサイト

Outline of Final Research Achievements

Chirality of cell structure is observed in vivo in Drosophila. However, bio-imaging analysis of cell chirality found in these cells has been difficult in vivo. Therefore, molecular mechanisms of cell chirality formation are still elusive. To overcome this problem, we attempted to develop a cell culture system to detect cell chirality. In this study, we developed a system to observe the chiral behavior of centrosome in cultured cells.

Free Research Field

細胞生物学