2015 Fiscal Year Final Research Report
The analysis of action mechanisms of secreted factors produced in pars tuberalis
| Project/Area Number |
26650109
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphology/Structure
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| Research Institution | Saitama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKATA Ichiro 埼玉大学, 大学院理工学研究科, 准教授 (80610831)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 下垂体隆起部 / 脳脊髄液 / 脳実質 |
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| Outline of Final Research Achievements |
In this study, horseradish peroxidase (HRP) was administered into the cistern magna in rats, and HRP penetration in the brain parenchyma was measured. The results showed that the penetration area of HRP in the brain parenchyma increased with time, and the HRP signals were observed in areas surrounding the lobule in the pars tuberalis. In contrast, HRP signals were not observed when HRP was injected intravenously. We also analyzed peptide extracts from the pars tuberalis and the cerebrospinal fluid by mass spectrometry. We showed that several peptides from the pars tuberalis were also found in the cerebrospinal fluid.
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| Free Research Field |
内分泌学
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