Screening of natural products for novel mannose-binding agents

2016 Fiscal Year Final Research Report

• Project/Area Number: 26660099
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bioorganic chemistry
• Research Institution: Nagoya University
• Principal Investigator: Nakagawa Yu 名古屋大学, 生命農学研究科, 准教授 (90452284)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 天然物 / 糖鎖 / pradimicin / 糖結合性分子 / レクチン / スクリーニング

Outline of Final Research Achievements

In an attempt to discover new natural products with D-mannose (Man)-binding ability, we have developed two screening methods using pradimicin A, a Man-binding antibiotic, and oligomannose-attached magnetic beads. Additionally, during the process to prepare a natural product library for the screening, we isolated a new natural product, named quinocidin, with cytotoxicity against HeLa-S3 cells derived from human cervix adenocarcinoma. Structural elucidation revealed that quinocidin possesses a 3,4-dihydroquinolizinium skeleton, which has very rarely been observed in natural products.

Free Research Field

天然物化学