Diagnostic halmarks and pathogenesis of canine inflammatory bowel disease and T cell lymphomas.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26660235
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: The University of Tokyo
• Principal Investigator: Uchida kazuyuki 東京大学, 農学生命科学研究科, 准教授 (10223554)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 犬 / 炎症性腸疾患 / T細胞性リンパ腫 / セリアック病 / グリアジン / 組織トランスグルタミナーゼ

Outline of Final Research Achievements

Molecular clonality analysis of T-cell receptor (TCR) genes for diagnosing T-cell lymphoma is widely used in veterinary medicine. However, differentiating chronic enteritis (CE) from intestinal lymphoma is challenging. We conducted serological examinations in combination IgA and IgG antibodies against gliadin and tissue transglutaminase (tTG) were quantitatively measured using ELISA. The conditions were classified according to the histopathological diagnosis, clonality analysis, and combined histopathological/clonality analysis. Histopathological analysis showed that dogs with intestinal lymphoma were likely to have high levels of serum IgA antibodies against gliadin and tTG, and serum IgG antibodies against tTG. Interestingly, dogs with intestinal lymphoma had a higher serum IgA titer against gliadin and tTG than did dogs with CE. These results suggest that canine CE and intestinal lymphoma may have a pathogenesis similar to human Celiac disease.

Free Research Field

獣医病理学