2015 Fiscal Year Final Research Report
Expression and storage of genetic information in insect cells
Project/Area Number |
26660269
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Insect science
|
Research Institution | Kyushu University |
Principal Investigator |
Kusakabe Takahiro 九州大学, (連合)農学研究科(研究院), 教授 (30253595)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | クロマチン構造 / インシュレーター / DNAメチル化 / 昆虫 |
Outline of Final Research Achievements |
High-ordered chromatin structure plays important roles in expression and storage of genetic information. In this study, we analyzed the molecular mechanisms of DNA methylation and its regulation in insect cells. DNA methylation-related genes were cloned from silkworm cells and their biochemical activities are characterized in detail. All together silkworm genes whose expression profiles were affected by DNA methylation were identified. Also the genes for insulator proteins blocking the effect of distant enhancers and spread of heterochromatin formation beyond chromatin loops were identified from silkworm cells and their structures and molecular functions were analyzed.
|
Free Research Field |
昆虫分子遺伝学
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