2015 Fiscal Year Final Research Report
The role of exosome derived melanoma cells in tumor immunity
| Project/Area Number |
26660294
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
AKAO Yukihiro 岐阜大学, 大学院連合創薬医療情報研究科, 教授 (00222505)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | エクソソーム |
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| Outline of Final Research Achievements |
This study revealed that TGF-β, which promotes the differentiation of T cells to regulatory T cells, was included in the exosomes derived from melanoma cells. This finding indicates that melanoma cells inhibit anti-tumor immunity via exosome secretion.
Visualization of exosomes is important to elucidate the role of exosomes in cell to cell comunication. Therefore, we constructed the expression vector of CD/GFP fusion protein using pEGFP-N1 vector. This vector makes us trace exosomes in vitro and in vivo.
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| Free Research Field |
獣医臨床腫瘍学
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