Detection of cancer stem cells and minimal invasion by DNP-MRI and hyperspectral enodoscopy redox imaging

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670016
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: Kyushu University
• Principal Investigator: NAKANO Kenji 九州大学, 先端融合医療レドックスナビ研究拠点, 教授 (00315061)
• Co-Investigator(Kenkyū-buntansha): HYODO Fuminori 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (10380693) ; MURATA Masaharu 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (30304744) ; HASHIZUME Makoto 九州大学, 医学系研究院, 教授 (90198664) ; CUI Lin 九州大学, 先端融合医療レドックスナビ研究拠点, 特任助教 (30717822)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 分子イメージング / ハイパースペクトル内視鏡 / レドックス / 微小癌浸潤診断 / 癌幹細胞

Outline of Final Research Achievements

The purpose of this study is to develop the non-invasive method for detecting minimal cancer invasion and cancer stem-like cells using hyperspectral endoscopic and DNP-MRI redox (metabolic) imaging technologies.
The eraly diagnosis for minimal disseminated cancers is difficult by conventional MRI, because it is difficult to discriminate the density between small volume of malignant ascites and tissue water components at the early stage of cancer progression. We have herewith met in success to develop the analysis method using DNP-MRI that visualize a minimal volume of malignant ascites as a diagnosis marker for early stage of peritoneal dissemination. Hyperspectral imaging discriminated high vascular flow and low-oxigen concentration in subcutaneous tumors from the surrounding normal counterparts.
These results indicate the potential of DNP-MRI and hyperspectral endoscope imaging as an useful diagnosis modalities for minimal cancer invasion and dissemination.

Free Research Field

分子腫瘍学、遺伝子・核酸治療