Intracellular roles of 2-acyl-lysophospholipids

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670021
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Tohoku University
• Principal Investigator: Aoki Junken 東北大学, 薬学研究科(研究院), 教授 (20250219)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: リゾリン脂質 / 脂肪酸 / ２－アシルリゾリン脂質

Outline of Final Research Achievements

Lysophospholipid is a kind of phospholipids with only one fatty acid either at the sn-1 or sn-2 position of glycerol. In contrast to the extracellular lysophospholipids, roles of intracellular lysophospholipids remain to be determined. In this study we tried to elucidate the role of intracellular lysophospholipids as well as its producing enzymes, intracellular phospholipase A1 (iPLA1). We found that, by inhibiting lysophospholipid acylation reaction, lysophospholipid level increased in cells. In addition, by over expressing iPLA1a, we increased the lysophospholipid level dramatically in the cells. Interestingly, we observed abnormal mitochondria and nuclear envelope in such cells, indicating possible role of intracellular lysophospholipids in regulating maintenance of these organelles.

Free Research Field

脂質生物学