Utilization of indigenous bacteria to produce recombinant proteins in animal body

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670025
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: KAITO CHIKARA 東京大学, 薬学研究科(研究院), 准教授 (60420238)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ロイヤルゼリー / 常在細菌 / フタホシコオロギ / カイコ

Outline of Final Research Achievements

This study identified bacterial species that exist in insect guts and examined its activity of genetic transformation and reattachment to insect guts. We isolated several bacterial species from stag beetles and the two-spotted cricket. We found that one of the bacterial species could be transformed with plasmid DNA and reattached to cricket gut.
In addition, this study searched biological molecules that increase insect body size. We found that administration of royal jelly to silkworms or crickets increases their body sizes. The result suggests that biological molecules in royal jelly have an activity to increase insect body size.

Free Research Field

微生物学