2016 Fiscal Year Final Research Report
Establishment of quantification system for human urinary LC3 as a noninvasive pharmacological evaluation system of mTOR inhibitor
| Project/Area Number |
26670081
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
KAJIWARA Moto
TAJIMA Soichiro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | バイオマーカー / mTOR阻害薬 / オートファジー / 薬剤性腎障害 / 慢性腎臓病 / 腎臓移植 |
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| Outline of Final Research Achievements |
Autophagy is an adaptation to starvation that escapes cell death through the reuse of amino acids, and is also activated by the inhibition of mTOR (mammalian target of rapamycin) activity. The increase of LC3 expression is well known as an indicator of autophagy. In the present study, a measurement system capable of quantifying the leakage of LC3 in human urine has been successfully established. LC3 in the urine is derived from cells constituting the kidney, and is an epoch-making technology that can noninvasively monitor the state of autophagy in the kidney. It is expected to be applied in the future as a state of the transplanted kidney tissue undergoing ischemia reperfusion injury and a pharmacological effect in human kidneys when mTOR inhibitors those induces autophagy is administered.
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| Free Research Field |
医療系薬学
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