Search for a novel biological regulatory system based on low temperature biology

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670110
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Gunma University
• Principal Investigator: OHNISHI HIROSHI 群馬大学, 大学院保健学研究科, 教授 (70334125)
• Co-Investigator(Renkei-kenkyūsha): HASHIMOTO Miho 学術振興会, 特別研究員 (90381087) ; Kusakari Shinya 東京医科大学, 医学部, 助教 (10510901) ; KODERA Yoshio 北里大学, 理学部, 准教授 (60265733) ; KANEKO Yoriaki 群馬大学, 大学院医学系研究科, 講師 (00334095) ; KITAMURA Tadahiro 群馬大学, 生体調節研究所, 教授 (20447262) ; KOBAYASHI Masaki 群馬大学, 生体調節研究所, 助教 (80373041)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: チロシンリン酸化 / 低体温 / ストレス / 生体保護

Outline of Final Research Achievements

The function and molecular mechanism of low temperature-induced tyrosine phosphorylation of a membrane protein SIRPα were investigated. As a result of examinations, there was a possibility that the low temperature-induced SIRPα signal might be related to suppressive action of hypothermia on memory formation and/or maintenance. In addition, possibilities that the SIRPα signal might enhance the susceptibility of cultured neurons to low temperature stress, and that it might contribute to the suppression of the LPS-induced systemic inflammatory response, were considered. In addition, possible molecular interaction between SIRPα and molecular chaperons, and the importance of ligand-biding to the extracellular region of SIRPα in cold-induced SIRPα phosphorylation, were indicated.

Free Research Field

神経化学