A novel therapeutic strategy for Alzheimer's disease based on the promotion of clearance mechanism of amyloid beta protein

2017 Fiscal Year Final Research Report

• Project/Area Number: 26670126
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Saitama Medical University
• Principal Investigator: Iwasa Kensuke 埼玉医科大学, 医学部, 助手 (00623703)
• Co-Investigator(Kenkyū-buntansha): 吉川 圭介 埼玉医科大学, 医学部, 講師 (10435860) ; 柳下 聡介 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第五部, 室長 (30585592)
• Co-Investigator(Renkei-kenkyūsha): Kondo Ryuitiro 九州大学, 農学研究科, 教授 (80091370) ; Shimizu Kuniyoshi 九州大学, 農学研究科, 准教授 (20346836)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: アルツハイマー病 / アミロイドβタンパク

Outline of Final Research Achievements

We found a natural resource derived component X, which increased Alzheimer Aβ42　protein in cellular level study. However, mice administrated X for long term were decreased Aβ42 in the brain and showed high level of learning and memory, compared to the control mice. Therefore, it was considered that X may promote the clearance mechanism of Aβ42 in the brain. In this study, we isolated and identified candidate compound Y from the component X with the cellular level study. We are preparing the mice administrated Y for long term. We are planning to Aβ42 production and ability of learning and memory in the Y administrated mice, to reveal the Aβ42 clearance mechanism of candidate compound Y.

Free Research Field

神経病理