New approach to develop Lactosome-based therapy for allergic disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670155
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: University of Fukui
• Principal Investigator: Sugai Manabu 福井大学, 学術研究院医学系部門, 教授 (90303891)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ラクトソーム / IgE / TGF-b / レチノイン酸

Outline of Final Research Achievements

Allergic hypersensitivity disorders are characterized by an excessive immunoglobulin E (IgE) response. IgE stimulates basophils and mast cells to release biologically active mediators in an antigen-specific manner. Steroids is commonly used for treatment of allergic disease to dampen inflammatory response. However, steroids also inhibit useful immune reaction. In this project, we try to develop new therapy for allergic disease by reducing IgE in vivo. For this purpose, we used “Lactosome” as a drug-delivery carrier.

Free Research Field

分子生物学