Novel signaling pathway which regulates skeletal muscle regeneration after injury

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670157
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Kobe University
• Principal Investigator: MINAMI YASUHIRO 神戸大学, 医学(系)研究科(研究院), 教授 (70229772)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: Ror1チロシンキナーゼ / 骨格筋損傷修復 / 筋衛星細胞 / 炎症性サイトカイン / 遺伝子発現制御 / 細胞増殖 / 幹細胞性維持

Outline of Final Research Achievements

The skeletal muscle is a highly regenerative tissue and/or organ, and tissue stem cells of the skeletal muscle, designated as skeletal muscle satellite cells (SCs), play important roles during regeneration of the skeletal muscle after its injury. In this study, we found that the receptor tyrosine kinase Ror1 is expressed selectively in SCs, and that expression of Ror1 is further induced by activation of NF-κB pathway which can be elicited by inflammatory cytokines, induced and secreted by immune cells following injury of the skeletal muscle. In this study, we also show that expression of Ror1, induced in SCs, plays an important role in regulating the behavior and function of SCs during regeneration of the skeletal muscle.

Free Research Field

分子細胞生物学