Is the cancer stem cell hypothesis useful to conquer radioresistant cancers?

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670184
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Tohoku University
• Principal Investigator: Fukumoto Manabu 東北大学, 加齢医学研究所, 教授 (60156809)
• Co-Investigator(Renkei-kenkyūsha): KUWAHARA YOSHIKAZU 東北大学, 加齢医学研究所, 助教 (00392225) ; SUZUKI MASATOSHI 東北大学, 加齢医学研究所, 助教 (60515823) ; URUSHIHARA YUUSUKE 東北大学, 加齢医学研究所, 博士研究員 (30722269)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 放射線耐性 / がん幹細胞 / 放射線治療 / 分割照射 / 病理学

Outline of Final Research Achievements

Recently, the cancer stem cell (CSC) is suggested to be resistant against therapy and recurrence. The fraction of CSCs was higher in clinically relevant radioresistant cells than in their parental cells. However, a long-term low dose fractionated radiation resulted in radioresistance of parental cells but did not increase CSCs fraction. We therefore conclude that the CSC phenotype is not involved in the acquisition of radioresistance of cancer cells.

Free Research Field

放射線病理学