2015 Fiscal Year Final Research Report
The regulation of humoral immune responses mediated by apoptotic cells clearance of follicular dendritic cells
| Project/Area Number |
26670185
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 濾胞樹状細胞 / アポトーシス / 胚中心形成 / 液性免疫応答 |
|---|
| Outline of Final Research Achievements |
Follicular dendritic cells (FDCs) locate within the follicules of lymphoid tissues and are the critical cells for the germinal center formation and humoral immune responses. By using novel isolation method for FDCs, we observed that FDCs engulf apoptotic cells via interaction between self-producing MFG-E8 and αV integrin. We also observed that IL-6 and CXCL-13 production by FDCs are regulated by the engulfment of apoptotic cells. Although we established mice whose αV integrin expression is specifically ablated on FDCs (FDCs-specific αV integrin null mice), germinal center formation and humoral immune responses seems to be comparable between FDCs-specific αV integrin null mice and control mice.
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| Free Research Field |
免疫学
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