2016 Fiscal Year Final Research Report
Preemptive medicine for allergic disorders: Significance of bacterial flora on the nasal cavity in atopic dermatitis
| Project/Area Number |
26670275
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | アトピー性皮膚炎 / ブドウ球菌 / 皮膚常在菌 / 鼻腔常在菌 / 16S rRNA解析 / 菌株解析 / POT法 / 質量分析計 |
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| Outline of Final Research Achievements |
Two specimens were picked up from diseased skin and nasal cavity of 25 patients with atopic dermatitis. 16S rRNA analysis showed the preponderance of Actinobacteria and Firmicutes on nasal cavity and Firmicutes and Proteobacteria on skin at the Phylum level. Three colonies of Staphylococcus were cultured and analyzed by POT (PCR based-open reading frame typing. The same POT type strains tended to be confirmed in both skin and nasal cavity of each patient.
The colonized bacteria are recruited from the nasal cavity of the patients, not environment, and are related to the deterioration of dermatitis.
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| Free Research Field |
臨床検査医学
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