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2016 Fiscal Year Final Research Report

Phthalate exposure and its effects on onset of puberty

Research Project

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Project/Area Number 26670321
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionHokkaido University

Principal Investigator

Araki Atsuko  北海道大学, 環境健康科学研究教育センター, 准教授 (00619885)

Co-Investigator(Renkei-kenkyūsha) KISHI Reiko  北海道大学, 環境健康科学研究教育センター, 特別招へい教授 (80112449)
Research Collaborator AITBAMAI Yu  北海道大学, 環境健康科学研究教育センター, 特任助教 (90752907)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords環境 / 衛生 / フタル酸エステル / 第二次性徴 / 性ホルモン
Outline of Final Research Achievements

Phthalates are ubiquitous environmental chemicals, which are widely used as plasticizes. Humans are exposed to phthalates since fetal life, and their endocrine disrupting properties has been concerned. However, prenatal exposure to phahalates and their effects on fetus onset of puberty in human are not well known. In this study, onset of puberty were examined among children registered to Sapporo cohort, the Hokkaido Study. Among those approached, 150 (45.6%) responded. Total effects of MEHP (primary metabolite of the most widely used phthalate, DEHP) levels in maternal blood was significantly positively associated with onset of puberty; natural log increase of MEHP (app. 2.67), onset of puberty delayed 7.17(95%CI:2.89-11.5)months among boys. Although progesterone and inhibin B were inversely associated with MEHP, none of hormones showed indirect effect of MEHP to onset of puberty. Girls did not show any association between MEHP, hormones, or onset of puberty.

Free Research Field

衛生学、公衆衛生学

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Published: 2018-03-22  

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