Prediction of metabolism and metabolome analysis of designer drugs using humanized liver mice

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670356
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Legal medicine
• Research Institution: Hiroshima University
• Principal Investigator: Ohta Shigeru 広島大学, 医歯薬保健学研究院(薬), 教授 (60160503)
• Co-Investigator(Kenkyū-buntansha): OKUDA KATSUHIRO 旭川医科大学, 医学部, 助教 (00389115) ; SANOH SEIGO 広島大学, 医歯薬保健学研究院(薬), 助教 (00552267) ; SHIMIZU KEIKO 旭川医科大学, 医学部, 教授 (90312462)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 危険ドラッグ / デザイナードラッグ / フェネチルアミン / カチノン / ドパミン / 体内動態 / ヒト肝細胞移植キメラマウス

Outline of Final Research Achievements

Recently, various dangerous drug-induced health injuries have reprted in humans. In this study, we have focused on phenethylamine and cathinone types in dangerous drugs. Phenethylamine derivatives changed locomotor activity in mice, which could be caused by inhibitory effects on dopamine uptake and high permeability at the blood-brain barrier. Oxidative metabolite of phenethylamine could become common metabolite of cathinone reduction, which was detected in chimeric mice with humanized liver after administration of cathinone derivative. These results contribute to criminal identification because there are a little imfomation regarding drug metabolism of dangerous drugs in humans.

Free Research Field

毒性学