Development of a novel pancreatic cancer rapid diagnostic method by the fucosyltransferases mRNA detection in peripheral blood

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670386
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Sapporo Medical University
• Principal Investigator: Kato Junji 札幌医科大学, 医学部, 教授 (20244345)
• Co-Investigator(Kenkyū-buntansha): TAKIMONO Risyu 札幌医科大学, 医学部, 准教授 (10336399) ; Osuga Takahiro 札幌医科大学, 医学部, 研究員 (40619714) ; Okagawa Yutaka 札幌医科大学, 医学部, 研究員 (50722386)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 膵癌 / フコース転移酵素 / digital PCR

Outline of Final Research Achievements

It is very useful for the diagnosis of cancer and monitoring of the curative effect if we can rapidly measure protein and a nucleic acid from cancer cell in the peripheral blood with high sensitivity. Numerous fucosylated antigens in sera like CA19-9 serve as tumor markers for pancreatic cancer. We developed a novel pancreatic cancer rapid diagnostic method by the fucosyltransferases mRNA detection in peripheral blood using Droplet Digital PCR (ddPCR).

Free Research Field

医歯薬学