Identification and purification of cardiac fibroblast-specific FGF23 receptor

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670412
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: KITAKAZE Masafumi 国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 部長 (20294069)
• Co-Investigator(Kenkyū-buntansha): 朝倉 正紀 国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 室長 (80443505) ; 瀬口 理 国立研究開発法人国立循環器病研究センター, 病院, 医師 (60570869) ; 中野 敦 国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 室長 (90648106)
• Research Collaborator: ITO Shin ; IMAZU Miki ; TAKASHIMA Seiji ; MIN Kyung-Duk ; SHINDO Kazuhiro ; YAMAZAKI Satoru ; FUKUDA Hiroki
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 循環器・高血圧 / トランスレーショナルリサーチ

Outline of Final Research Achievements

We have reported that serum concentration of fibroblast growth factor 23 (FGF23) is significantly increased in patients with heart failure, and FGF23 level is associated with the extent of cardiac fibrosis. These findings led us to investigate the association between FGF23 and cardiac fibrosis. In this study, we found that FGF23 leads to transdifferentiate from fibroblast into myofibroblast, and then increases collagen gene expression using human cardiac fibroblast. We also identified FGF23 receptor in cardiac fibroblast. These results suggest that FGF23 may be a novel therapeutic target for heart failure.

Free Research Field

循環器内科学