• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2015 Fiscal Year Final Research Report

The therapeutic starategy by Ghrelin targeting against mitochondria dynamics

Research Project

  • PDF
Project/Area Number 26670433
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
Research InstitutionKeio University

Principal Investigator

Wakino Shu  慶應義塾大学, 医学部, 准教授 (50265823)

Co-Investigator(Kenkyū-buntansha) Shinozuka Keisuke  慶應義塾大学, 医学部, 助教 (00594558)
Itoh Hiroshi  慶應義塾大学, 医学部, 教授 (40252457)
Project Period (FY) 2014-04-01 – 2016-03-31
Keywordsグレリン / ミトコンドリア / マイトファジ― / fission / fusion
Outline of Final Research Achievements

Ghrelin have protective effects against renal impairment by reducing renal mitochondria-derived oxidative stress and by improving mitochondrial function. Recent study revealed that mitochondria dynamics plays an important role in the initiation and progression of renal failure. We investigate the efficacy of Ghrelin for the treatment of diabetic kidney impairment. C57BL/6 mice at the age of 8 weeks were subjected to streptozotosin injection in order to render diabetic. After the onset of diabetes, Ghrelin at the dose of 300μg/kg was administered by daily intraperitoneal injection. We found that swelling of mitochondria and the disruption of mitochondrial cristae in the kidney were ameliorated by the treatment with Ghrelin. Ghrelin increased the expressions of genes related to mitophagy including PINK1 and Perkin, although it did not have any effect on the genes related to mitochondria fission or fusion. We concluded that Ghrelin has renal protective effects in diabetic kidney disease.

Free Research Field

腎臓病学、内分泌学、代謝学、

URL: 

Published: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi