2016 Fiscal Year Final Research Report
GLP-1 and insulin synergize to activate vagal afferent nerves leading to central regulation of metabolism, feeding and blood pressure
| Project/Area Number |
26670453
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | インスリン / GLP-1 / 求心性迷走神経 / 糖代謝 / 摂食 |
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| Outline of Final Research Achievements |
GLP-1 and insulin increased cytosolic Ca2+ ([Ca2+]) in isolated neurons form vagal afferents. GLP-1 and insulin, at low concentrations incapable of inducing [Ca2+] responses, in combination either induced [Ca2+] increases with greater amplitude in responsive neurons or produced [Ca2+] increases in unresponsive neurons, showing additive or synergistic effects. We found a sugar that induced both GLP-1 and insulin release. This sugar suppressed food intake and promoted glucose tolerance, and when chronically administered it ameliorated hyperphagia, obesity and glucose intolerance. All these effects were inhibited in GLP-1 receptor KO mice and by vagotomy.
These data suggest that GLP-1 and insulin act synergistically to activate vagal afferent neurons and regulate metabolism.
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| Free Research Field |
代謝学、生理学
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